Robust flu protection may rely on B cells that are long-lived residents in the lungs

Deep in the lungs, resident memory B cells stand guard against influenza reinfection—but whether they remain there may depend ...
The New England Journal of Medicine

CD19 CAR T-Cell Therapy for Autoimmune Hemolytic Anemia

In patients with autoimmune hemolytic anemia (AIHA), the risk of relapse is high owing to persistent autoreactive B-cell activity. Multirefractory AIHA is a more advanced stage of disease that is ...
Morningstar

CREATE Medicines Demonstrates Complete B Cell Depletion and Repeatable Dosing in Non-human Primates with In Vivo CAR-T Platform

Industry-leading non-human primate (NHP) data validates CREATE's differentiated receptor design, targeted RNA-LNP platform, and ability to repeat dose Clinical entry planned H2 2026 CAMBRIDGE, Mass., ...

Verismo Therapeutics Presents Preclinical Data at AACR 2026 for SynKIR(TM)-310 KIR-CAR Indicating Superior Preclinical Activity in B Cell Malignancies and Early Clinical Efficacy

Preclinical data showed enhanced anti-tumor activity and reduced cytokine release compared to conventional single-chain CAR T approaches -- Early clinical case from CELESTIAL-301 trial, the ...
Medscape

Epstein-Barr Virus Alters B Cells, Possibly Driving Lupus

Epstein-Barr virus (EBV) infected and reprogrammed autoreactive B cells in patients with systemic lupus erythematosus (SLE) to become activated antigen-presenting cells. EBV-infected B cells in ...
EurekAlert!

Transcription factor T-bet regulates memory B cell subsets

T-bet expression is required for persistence of memory B cells that have rapid differentiation potential to become antibody-producing plasma cells in response to a second infection BIRMINGHAM, Ala. – ...