CAPTION: (Top) Condensins seem to act as a molecular crosslinkers to make loops. (Bottom, left) Condensins (red) locate around chromosome center. (Bottom, right) Nucleosomes around the periphery ...

Researchers used miniature human brains grown in the lab to uncover why certain genetic mutations lead to abnormally small brains. Changes in actin disrupted the orientation of early brain cell ...

Researchers at the Centre for Genomic Regulation (CRG) reveal that metabolic enzymes known for their roles in energy production and nucleotide synthesis are taking on unexpected "second jobs" within ...

Over the past decades, large-scale human genetic studies have identified numerous risk genes and variants associated with complex diseases and traits.

Scientists have recently been learning more about the importance of small bits of circular genetic material known as extrachromosomal DNA (ecDNA). These little circles of DNA can hitch a ride with ...

A microscopic flaw in the brain’s cellular scaffolding can shape brain size for life.

An organism grows and repairs its body using a form of cell division known as mitosis. To divide, a cell must replicate the chromosomes, which carry the DNA (the instructions needed to build the body) ...

About 100 cells divide every second in our body. A key protein in cell division is a protein kinase termed Plk1, because it activates other proteins involved in this process. Plk1 is also ...

The centromere is necessary for the transport of chromosomes during cell division and, therefore, for the correct ...

Arteriovenous malformations, a hallmark of hereditary hemorrhagic telangiectasia, may be driven by endothelial cell-cycle acceleration via CDK6, suggesting potential for repurposing CDK6 inhibitors.

Experiments on an ultra-rare genetic mutation that causes neurodegeneration in children have helped uncover a new mechanism ...

When Dr. Ambroise Wonkam walked into a panel on medical genetics out of curiosity, he had no idea it would shape the course of his career. Born in Cameroon, Wonkam has dedicated his career to studying ...