The vast majority of new small-molecule drug candidates are chiral, and methods must be identified for obtaining the desired enantiomer in high purity. A common approach is to separate the enantiomers ...

Direct chromatographic separations are generally preferred to indirect approaches, for example, to avoid extensive sample preparation and problems as a result of racemization, kinetic resolution and ...

The first chiral, nanosized metal-oxide complexes that retain their enantiomeric purity under chemical and thermal conditions that normally cause racemization have been synthesized and characterized.

The recognition of chirality in bioactive molecules is as old as modern organic chemistry itself. Pioneering work by Jean-Baptiste Biot, Louis Pasteur, Emil Fischer, and J. vant Hoff established ...