Ever since variants in the gene for TMEM106b were tied to frontotemporal dementia, Alzheimer’s, and other neurodegenerative diseases, this endolysosomal protein has been a head-scratcher for ...

Figure 2. Diagrammatic representation of kodikaz therapeutic solutions’ zip-code technology application to various human diseases. The complex interplay between extracellular genetic material and the ...

Long Interspersed Nuclear Element-1 (LINE-1 or L1) is the only active, self-copying genetic element in the human genome—comprising about 17% of the genome. It is commonly called a "jumping gene" or ...

A joint research group team led by Sayuri Tsukahara and Tetsuji Kakutani of the University of Tokyo has clarified a mechanism of how retrotransposons, genetic elements that can "jump around" ...

Inflammasomes are huge, multi-protein complexes inside cells that spark inflammation when they sense danger. Inflammasomes can also sound the alarm when no pathogens are present, contributing to ...

The recent approval of a CRISPR-Cas9 therapy for sickle cell disease demonstrates that gene editing tools can do a superb job knocking out genes to cure hereditary disease. But it's still not possible ...

Retrotransposons are evolutionarily ancient genes that “jump” around the human genome leaving a slew of repeat nucleotide sequences in their wake. These repeats can disturb normal gene function.

You say tomato, I say retrotransposon The oblong shape of some tomatoes arose from a gene duplication caused by a selfish genetic element, according to a ...

Researchers demonstrated that the microscopic worm C. elegans uses a retrotransposon called Cer1 to transfer a learned behavior (avoidance of a pathogenic bacterium) between worms. In earlier work, ...