P-cadherin is a protein commonly found on malignant cancer cells and has been used as a target for antibody-based cancer treatments. UC Davis biomedical engineers have discovered that when an antibody ...

In a major brain science breakthrough, New Orleans-based researchers and collaborators have discovered a nerve signaling mechanism that takes place outside the cell, flipping on a 'pain switch.' This ...

Pro-inflammatory M1 macrophages involved in immune responses accelerate the progression of melanoma through the extracellular ...

Plants mobilize their immune defenses far earlier than scientists have believed for decades—and through a previously overlooked early signaling mechanism—according to a new study published in Nature ...

Researchers have investigated the role of a certain enzyme in regulating energy in muscle and exercise performance for ...

Drawing inspiration from natural cell signaling cascades, chemists at Université de Montréal (UdeM) have developed a DNA-based signaling cascade that allows them to quantify and report via an easily ...

Retinal degeneration leads to irreversible vision loss, significantly impacting quality of life. Approximately 19.83 million Americans over 40 have age-related macular degeneration (AMD), a leading ...

A new method exposes key details of the mechanism behind calcium signaling in prokaryotes for the first time. Working in a Listeria monocytogenes model, researchers from Umeå University (Sweden) led ...

Cellular differentiation of stem cells into specialized cells requires many steps, including division, to create more cells; fate determination, which is a commitment to a specific lineage or ...

A new study shows how an anticancer drug triggers an 'outside in' signal that gets it sucked into a cancer cell. The work reveals a new signaling mechanism that could be exploited for delivering other ...