Role of the RAAS in the Pathophysiology of Heart Failure ACE inhibitors have no effect on angiotensin II formed by alternate pathways. In contrast, ARBs would be expected to inhibit the biologic ...

Research that focused on blocking the renin-angiotensin system (RAS) led to the discovery of ACE inhibitors, which proved efficacious in the treatment of hypertension, various cardiovascular disorders ...

The randomized Phase 2b ASPIRE trial successfully completed planned enrollment of over 360 patients, reflecting strong execution and robust site engagementASPIRE is designed to assess the effect of bu ...

Vasodilatory shock is a life-threatening syndrome that requires immediate treatment; conventional vasopressors have a narrow therapeutic window and toxicities at high doses. New research findings are ...